Preheat your oven to 375°F (190°C). Roll out the pie crust and press it into a 9-inch pie dish. Prick the bottom with a fork and bake for 8-10 minutes until lightly golden.

In a skillet, cook the ground beef over medium heat until browned. Drain any excess grease. Stir in garlic powder, onion powder, Italian seasoning, salt, and pepper.

Spread half of the pizza sauce over the bottom of the pre-baked crust. Add the cooked ground beef evenly on top.

Sprinkle 1 cup of mozzarella cheese over the beef layer, followed by the remaining pizza sauce.

Add the rest of the mozzarella cheese and cheddar cheese on top. Arrange your favorite pizza toppings, like pepperoni or veggies, on the cheese layer.

Bake in the preheated oven for 20-25 minutes, or until the cheese is melted and bubbly.

Let the Pizza Burger Pie cool for 5 minutes before slicing and serving.